Associate Professor
Division of BioMedical Sciences
Heart and Stroke Foundation New Investigator
PhD (University of Western Ontario)
Email: Jesseltine@mun.ca
I grew up in a small town in south western Ontario made famous for killing Jumbo the Elephant. I completed my PhD at Western University studying GPCR signal transduction and protein trafficking. After a brief postdoctoral fellowship in Seattle, WA, I returned to Canada to study cell-cell communication. I discovered pluripotent stem cells quite late in my training and was blown away by the idea that they can become any cell type in the body and that they can be used for personalized regenerative medicine when generated from individuals with disease.
Since moving to beautiful Newfoundland I am tackling how cells communicate with each other during cell fate specification. Additionally, with the support of the sudden cardiac death team we use patient-derived iPSCs in order to understand hereditary heart disease in Newfoundland.
Science Technician
I am from Nanjing, a pretty city in China. I have studied in Canada since high school. I graduated from University of Toronto where I double majored in Cell & Molecular Biology, and Fundamental Genetics & its Application. During my undergraduate study, I developed my interest in stem cell research. In the Esseltine laboratory, my project is gap junction based stem cell communication which is a continuation of my journey in the field of stem cell studies.
Camila Fuchs, MSc
Science Technician
I was born in Brazil but grew up in China before moving to Newfoundland to start my BSc in Biology at Memorial University. I started in the lab through a shadowing opportunity and was fascinated with the work being done, now I am currently completing my SURA program where I am researching about the TMEM43 protein which plays a great factor in a hereditary heart disease in Newfoundland.
Sanaz Sobhani, MSc
PhD Student
Growing up in Tehran, Iran, I earned a Master’s in Genetics from Tehran Science and Research University, where I focused on signal transduction in colorectal cancer. After gaining valuable experience in medical genetics labs and teaching at the university level, I moved to Canada to pursue a second Master’s in Biomedical Sciences at Memorial University of Newfoundland. Now, I am thrilled to be a PhD student in Dr. Jessica Esseltine’s laboratory, where my research explores inherited cardiomyopathy in Newfoundland patients using patient-derived stem cells.
Sareh Khoshbakht, MSc
PhD Student
I was born and grew up in Sirjan, a small city in Iran, I completed my first Master’s in Human Genetics from the University of Social Welfare and Rehabilitation Sciences, Tehran, Iran, where I developed a strong foundation in genetic disorders. I then pursued a second Master’s in Biomedicine at UiT The Arctic University of Norway, focusing on iPSC-derived cardiomyocytes (iPSC-CMs). Driven by a passion for translational stem cell research, I moved to Canada to join Dr. Jessica Esseltine’s laboratory as a PhD student. Currently, my research focuses on patient-derived iPSC-CMs carrying mutations in cTnT and cTnI, aiming to uncover mechanisms underlying inherited cardiomyopathy.
Ian Tompkins, MSc
MSc Student
I have lived in Newfoundland my entire life, although you couldn't tell because I'm quite directionally impaired. I completed both an Honours and a Master's in analytical/ocean chemistry at Memorial University of Newfoundland where I specialized in extracting protein-like structures from rivers and ocean waters. I made a full pivot into the biomedical field, and I am currently pursuing my graduate studies in the Esseltine Lab, where research is centred on heart arrhythmias linked to the "Newfoundland Curse." This condition is associated with a genetic variant in the TMEM43 gene, which can lead to sudden cardiac death in otherwise healthy young individuals.